Senolytic Protocol

Cellular senescence is a biological process in which cells permanently stop dividing but do not die. Instead, they accumulate in tissues and secrete a mixture of inflammatory cytokines, chemokines, and proteases known as the senescence-associated secretory phenotype (SASP). This chronic inflammatory signaling contributes to age-related diseases, tissue fibrosis, and immune dysfunction.

Senolytic interventions aim to selectively clear these senescent cells, potentially reducing chronic inflammation and supporting tissue regeneration. This is a rapidly evolving area of scientific research with promising preclinical results and early clinical evidence.

Important: Senolytic therapy is an investigational approach. While preclinical and early human studies show promising results, large-scale clinical trials are still ongoing. At St. George Hospital, senolytic protocols are offered within the framework of individualized medicine and with full transparency about the current state of evidence.

Senolytic protocols at St. George Hospital are considered for patients with:

• Age-related functional decline
• Elevated markers of cellular senescence
• Chronic low-grade inflammation without identifiable cause
• Chronic disease with suspected senescent cell burden
• Interest in evidence-informed longevity medicine

This protocol is not presented as a cure for any condition. Treatment goals are discussed openly with each patient, including the limitations of current evidence.

Could this belong in your plan?

That depends on your findings, not on the therapy. Send what you have with a short history; a physician reads it before the video call and tells you whether this treatment belongs in your program.