Evidence is graded on this page in four words: strong, moderate, emerging and limited. A component graded limited or emerging is an individual treatment attempt decided with the patient after medical consultation, and the physician says so before you consent.
Hyperthermia with radiotherapy in recurrent breast cancer: strong. Five randomized trials in 306 patients with recurrent or inoperable primary breast cancer found complete responses in a larger share of patients when hyperthermia was added to radiotherapy, with the greatest effect in recurrences in previously irradiated areas where only low radiation doses were possible (Vernon et al., Int J Radiat Oncol Biol Phys, 1996). A randomized trial of superficial tumors with measured thermal dose found the same local-control benefit, and no overall survival benefit (Jones et al., J Clin Oncol, 2005). A meta-analysis of 34 studies in locoregional recurrent breast cancer confirmed the higher complete-response rate with hyperthermia added (Datta et al., Int J Radiat Oncol Biol Phys, 2016).
Mistletoe: moderate for quality of life. A meta-analysis of nine randomized trials in breast cancer found a medium-sized improvement in quality of life with mistletoe extracts (Loef et al., Integr Cancer Ther, 2023). Mind-body and supportive measures: the Society for Integrative Oncology guideline recommends meditation, yoga, relaxation and music therapy for anxiety and mood during breast cancer treatment and acupressure or acupuncture for chemotherapy-induced nausea, and finds no strong evidence for ingested supplements against treatment side effects (Greenlee et al., CA Cancer J Clin, 2017); the American Society of Clinical Oncology endorsed that guideline (Lyman et al., J Clin Oncol, 2018). Whole-body hyperthermia, IPT, dendritic cell therapy and the estrogen metabolism work: emerging to limited.
What the evidence does not show is longer survival from hyperthermia in breast cancer: the randomized trials measured local control, and the hospital does not claim more than they found. The article on mistletoe therapy in cancer in our journal goes through the mistletoe trials in more detail.