Intravenous administration of nicotinamide adenine dinucleotide (NAD+) to support mitochondrial function, cellular energy production, and DNA repair mechanisms.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell that plays a central role in energy metabolism, DNA repair, and cellular signalling. NAD+ levels naturally decline with age and are further depleted by chronic illness, infection, and metabolic stress.
Intravenous NAD+ therapy delivers this essential molecule directly into the bloodstream at concentrations that cannot be achieved through oral supplementation, helping to restore cellular function in patients with mitochondrial dysfunction, chronic fatigue, and neurodegenerative conditions.
NAD+ is infused intravenously over 2-4 hours at carefully titrated rates to minimize side effects. Once in the bloodstream, NAD+ is taken up by cells throughout the body where it participates in over 500 enzymatic reactions.
Key mechanisms include: fuelling the mitochondrial electron transport chain for ATP production; activating sirtuins (SIRT1-7) involved in DNA repair, gene expression, and cellular stress response; supporting PARP enzymes critical for DNA damage repair; and modulating inflammatory pathways through CD38-dependent mechanisms.
NAD+ therapy is prescribed based on clinical assessment and metabolic testing. Our physicians will determine the appropriate dosing and treatment duration for your needs.
NAD+ infusions are administered over 2-4 hours in a comfortable infusion setting. The infusion rate is started slowly and gradually increased as tolerated. Some patients experience mild nausea, chest tightness, or muscle cramping during the infusion, which typically resolves by reducing the infusion rate. Most patients report improved energy and mental clarity following a course of 3-5 sessions.
NAD+ biology is an active area of scientific research. Preclinical studies published in journals including Cell, Nature, and Science have established NAD+’s role in mitochondrial function and ageing. Clinical evidence for intravenous NAD+ therapy is still accumulating, with early studies and case series showing improvements in fatigue, cognitive function, and metabolic markers. At St. George Hospital, NAD+ therapy is used as part of comprehensive treatment protocols rather than as a standalone intervention.
Contact our medical team to discuss whether NAD+ infusion therapy may support your treatment goals.
