Standard blood tests rarely reveal the biological dysfunctions underlying CFS/ME. Our comprehensive diagnostic protocol examines mitochondrial function, immune status, chronic infections, hormonal balance, and autonomic regulation to identify treatable causes.
The diagnosis of CFS/ME is typically made by exclusion — ruling out other conditions and then concluding that fatigue of unknown cause persists. This approach tells the patient what they do not have, but never explains what they do have or why.
At St. George Hospital, we go beyond exclusion. Our diagnostic approach actively seeks the biological dysfunctions driving each patient’s symptoms. We test mitochondrial energy production, map immune dysregulation, screen for chronic and reactivated infections, evaluate hormonal pathways, and assess autonomic nervous system function.
The result is not merely a label, but a mechanistic understanding of why you are sick — which directly informs a targeted treatment plan.
A detailed review of your symptom timeline, onset triggers, prior diagnoses, treatments tried, functional capacity, and quality-of-life impact. We use validated CFS/ME assessment tools to quantify symptom severity.
ATP profile testing, organic acid analysis, and oxidative stress markers reveal the efficiency of cellular energy production. These tests identify specific metabolic blocks that can be targeted with therapy.
Mitochondrial testing frequently shows impaired ATP synthesis, blocked electron transport chain complexes, and elevated markers of oxidative damage. This directly explains the energy deficit that defines CFS.
Natural killer cell cytotoxicity is consistently reduced in CFS patients, indicating impaired immune surveillance. This may explain susceptibility to viral reactivation and persistent infections.
Elevated antibody titers to EBV (especially early antigen), CMV, or HHV-6 suggest ongoing viral activity that may be driving chronic immune activation and inflammation.
Subclinical hypothyroidism, adrenal insufficiency, low sex hormones, and vitamin D deficiency are frequently found and contribute to fatigue, cognitive dysfunction, and immune impairment.
Increased intestinal permeability ("leaky gut") allows bacterial endotoxins to enter the bloodstream, triggering systemic inflammation and contributing to both fatigue and neurological symptoms.
Heart rate variability testing often reveals sympathetic dominance and reduced parasympathetic tone, indicating a nervous system stuck in a stress response pattern.
Once we have identified the specific biological dysfunctions driving your CFS, we design a targeted treatment plan that addresses each finding. No two treatment plans are identical because no two patients have exactly the same pattern of dysfunction.
Intermittent hypoxia-hyperoxia training stimulates mitochondrial regeneration, a core target in chronic fatigue recovery.
Intravenous NAD+ supports cellular energy metabolism and mitochondrial repair identified as impaired in diagnostic testing.
Medical ozone improves oxygen utilization and modulates immune function, targeting findings from CFS diagnostic panels.
Addresses hormonal imbalances -- thyroid, adrenal, and sex hormones -- frequently uncovered during CFS diagnostic workup.
Stop settling for “we cannot find anything wrong.” Let our diagnostic team find the real cause of your fatigue.
