Targeted Hyperthermia

Local-Regional Hyperthermia

Local-regional hyperthermia delivers focused heat directly to tumor sites, damaging cancer cells while preserving surrounding healthy tissue. It is one of the most effective methods for enhancing the impact of conventional cancer treatments.

Overview

What Is Local-Regional Hyperthermia?

Local-regional hyperthermia (LRH) is a targeted heat treatment that raises the temperature of a specific tumor or body region to between 40 and 44 degrees Celsius. Unlike whole-body hyperthermia, LRH focuses energy precisely on the affected area.

This selective heating damages cancer cell membranes, disrupts their ability to repair DNA, and makes them more vulnerable to chemotherapy and radiation therapy.

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Treatment room at St. George Hospital Bad Aibling Germany
Mechanism

How Does It Work?

Using electromagnetic energy delivered through specialized applicators placed on the body surface, heat is directed deep into the tissue where the tumor is located. The system allows precise targeting and temperature control.

The treatment is non-invasive and painless for most patients. Temperature monitoring ensures the target zone reaches therapeutic levels while surrounding tissue remains unaffected.

Indications

What Conditions Does It Treat?

Is This Therapy Right for You?

Our physicians will recommend specific treatments only after a thorough assessment of your individual case.

Patient Experience

What Does a Session Look Like?

A local-regional hyperthermia session lasts approximately 60 minutes. The patient lies comfortably while the applicator is positioned over the treatment area. There is no anesthesia required. Most patients tolerate the treatment well, describing a sensation of deep warmth. Sessions are typically administered two to three times per week as part of a multimodal treatment program.

Research

Evidence & Safety

Local-regional hyperthermia is one of the most extensively researched forms of hyperthermia. Multiple randomized controlled trials have demonstrated improved tumor response rates and survival when LRH is added to chemotherapy or radiation. It is included in treatment guidelines from the European Society for Hyperthermic Oncology (ESHO).

Cross-Department Use

Used in These Departments

Learn More About Local-Regional Hyperthermia

Contact our medical team to discuss whether this therapy may be appropriate for your condition.